The Glutathione Revolution with Dr. Nayan Patel

[Intro] Hey, everyone. Welcome back to Facially Conscious with myself, Trina Renea, esthetician, Dr. Vicki Rapaport, dermatologist, Rebecca Gadberry, the cosmetic ingredient guru, and our fabulous, overly-educated consumer, Julie Falls. We are gathered here together with you to talk about this crazy world of esthetics. It's confusing out there in this big wide world. 

That's why we are here to help explain it to you all, subject by subject. We will be your go-to girls, and from our perspective without giving medical advice, we will keep things facially conscious.

Let's get started. 

01:00 Trina Renea: Good afternoon, everybody. Welcome to Facially Conscious. We are so excited for today because there is some revolutionary information we have for you and it's exciting times. We're in 2023. 

01:15 Rebecca Gadberry: Did you mean to say revolutionary, because our guest wrote The Glutathione Revolution? 

01:22 Trina Renea: I was doing a play on words.

01:24 Rebecca Gadberry: Oh, were you? You just kind of slipped that in right there. 

01:28 Trina Renea: Welcome, everyone. Hello, hello, hello. 

01:30 Julie Falls: Good afternoon, everybody. 

01:31 Trina Renea: Good afternoon. How are you doing today? 

01:34 Rebecca Gadberry: We're doing well. 

01:36 Trina Renea: Good. We are really excited to have our guest today. His name is Dr. Nayan Patel. Is that correct, Nayan? 

01:47 Dr. Nayan Patel: Yes, it is. Thank you. 

01:50 Rebecca Gadberry: Good. And he's a lovely gentleman, but more than that, he has had over three decades of working in the longevity and health area as one ages. His name is Dr. Nayan Patel, and he is an authority, one of the world's leading authorities, on glutathione, which is what is considered your body's master antioxidant. He's going to talk a lot about glutathione today.

You were kind of talking about revolutionary ideas on glutathione and how much it works in our bodies to ensure the immune system functions properly. It's essential for building up tissue and repair and for making necessary chemicals and proteins that our bodies needed, especially inside the cell. 

The abbreviation for glutathione is GSH. And if you're a listener, you may have seen that abbreviation. What it actually means is glutathione, which is what we call a tripeptide. It's made out of three different amino acids that make it a rather large molecule. This can make it difficult to work with as a cosmetic chemist. I’ve had challenges in working with it over the years.

I'm going to be starting off by simply asking Dr. Patel what's going on with that. But before I go on and ask him that, I do want to say that besides being a tissue-rebuilding molecule, it also has detoxifying power, not only in the body but in the cells. It helps to defend the skin from environmental stress. It helps to prevent signs of aging, from exacerbating or even starting, and it helps to detoxify the skin. 

Now, some of you may have heard me pooh-pooh the idea of detoxifying the skin. So I'm going to ask Dr. Patel to explain what that means and why it happens or how it's happened. 

But the most exciting thing that we have with Dr. Patel today is that he is not only very knowledgeable about glutathione, but he is also an inventor. He developed this new delivery system to cut through the barrier, not cut through the barrier, I guess it's a cutting-edge system, but to take the glutathione molecule through the skin's barrier and deliver it into the body. This is a sub-nano technology, so it's even tinier than nano is. What is tinier than nano, Dr. Patel? Go ahead.

04:50 Dr. Nayan Patel: Nanotechnology is anything between 2 to 500 nanometers, is nanotechnology, which is most of the molecules. A pretty small molecule. Sub-nano is under one nanometer. 

05:02 Rebecca Gadberry: Oh, my goodness. Really? That is like a grain of sand would be a partial part of a grain of sand is one nanometer.

05:13 Dr. Nayan Patel: Well, the grain of sand you can see it at least. You can’t even see nanotechnology particles. Forget the sub-nano. So, much smaller.

05:21 Rebecca Gadberry: So, any nano you can't see. And if you remember back to the ‘70s, Nano-Nano with Robin Williams. But anyway, that's a different story. 

What we want to talk about is glutathione. I'm going to play the skeptic here and I'm going to say it's been my experience in formulating skincare products with glutathione that it's difficult to get into the skin. We've always used a carrier or something like a liposome. But it's also very difficult to get it into the cell, unless it's manufactured in the cell already.

So I would love to have you correct me and educate me on that, and everybody else. 

06:08 Dr. Nayan Patel: No. Absolutely. What you're saying is absolutely 110% correct. Glutathione cannot enter any cell wall whatsoever. Doesn't matter what the technology is, until now. You can use you can use liposome forms. Even liposomes form cannot literally enter your blood cells or your skin cells. It can transfuse through it, but it can never enter it. That is always true.

As a pharmacist, I was also making intravenous form of glutathione for years, for 20 years, and even the intravenous form of glutathione, even though you're injecting it straight into your bloodstream, that glutathione doesn't even enter the red blood cells. It stays in the plasma, in the water part of your blood, and your kidney filters it out and you're literally peeing the glutathione out of your body within 15 minutes.

07:02 Rebecca Gadberry: So it's not doing anything while it's in there. 

07:03 Dr. Nayan Patel: It's not thing. So your statement is absolutely correct when you say that glutathione cannot enter the cells, unless it is produced inside your body, which what we call is endogenous production of glutathione.

07:17 Rebecca Gadberry: Right. Which ‘endo’ means inside, ‘genous’ means to make, so to be made inside. 

07:24 Dr. Nayan Patel: That is true. But that's where I come into play 14 years ago when I first discovered a way to actually deliver glutathione into your body.

07:36 Rebecca Gadberry: Oh, I wish I would have known about you 14 years ago. I could have saved myself a lot of problems. So tell us about this technology. 

07:46 Dr. Nayan Patel: The technology is rather novel because there has not been a single product ever used to make using this technology. 

07:57 Rebecca Gadberry: When you say novel, that always tells me it's patented, because novel is part of the definition of a patent. So is this patented? 

08:05 Dr. Nayan Patel: We do have three patents approved in United States and China. We have six more patents that are pending at this point all over the world. And we do have a process of writing another dozen, half a dozen to a dozen more patents as the research keeps on evolving. The attorneys are getting paid very well to do these patents for us. 

08:31 Rebecca Gadberry: As they do.

08:35 Dr. Nayan Patel: The purpose is not to get it patented. The purpose is to keep on doing the research that is necessary to learn about this miraculous molecule that our body produces so much of it.

08:46 Rebecca Gadberry: Tell us about the molecule before we understand why we need it to go into the body with your technology. 

08:54 Dr. Nayan Patel: First of all, glutathione is the most abundant molecule found inside your body, next to water. We don't produce water, but a little bit. We drink every single day. But our body produces the most is glutathione, and it's a very simple molecule. It takes three amino acids, glutamic acid, glycine, and cysteine. It takes three amino acids and combines them to make a chain of amino acids, which we call proteins. This is the simplest form of protein that a body produces.

It doesn't take a lot of energy, but we produce an abundance of it because every cell in your body requires glutathione to stay alive, to stay energized. So every single cell needs this glutathione so our body is going to produce abundantly as much as we need. 

09:48 Trina Renea: So why do we need to get more into the body if our body produces enough that we need?

09:54 Dr. Nayan Patel: Yeah, that's always the question, right? And you're right, we don't need to take glutathione from outside sources all the time, because why? Our body has reserves made to produce glutathione. Our body is made to recycle the production of glutathione so we don't lose every single thing.

But our needs, our human needs don’t change. As we get older, our needs are almost the same, if not increased as we age. But as we age, our body's ability to produce glutathione actually stays the same or decreases as we age. And so there is a gradient that increases between how much you can produce and how much we need. 

As the gradient increases as we age, we have a problem. And you can literally see that. As in, “Oh, my God, in the last five years, I've aged so much.” And you see it on your skin. Keep in mind, your skin is just a reflection of how your organs are inside. 

11:00 Rebecca Gadberry: Exactly. 

11:01 Dr. Nayan Patel: You don't see organs. 

11:03 Julie Falls: So with your formula, you have seen— well, first of all, if you could tell us exactly what…

11:08 Trina Renea: His delivery system. 

11:10 Julie Falls: Yes, your delivery system. 

11:11 Dr. Nayan Patel: Absolutely. So the delivery, what we have done is, again, I wish I was a genius scientist, but I'm not. 

11:19 Rebecca Gadberry: It sounds like you are. 

11:24 Dr. Nayan Patel: You know, I was just a good observationist. That's what I consider. Most scientists are good at observing things. And when I observed what I created in my lab, the glutathione molecule, the stable form of glutathione, I had no idea what I had in my hands until a year later. I keep a cup on my desk and saying, “What is this? How come this is not getting oxidized? How come this is not getting destroyed by the water? It is such a delicate molecule.”

One year goes by on my desk, sitting with this vial of glutathione in a solution and hasn't destroyed yet. And a year later, I realized, “You know what? There's something up with this molecule. What did I do a year ago?”

Went back, looked at all my research and said, “What did I do?” That's when I figured out what I've actually done. What I have done was I protected the glutathione molecule from getting oxidized, which is the number one reason why we produce glutathione is for antioxidant effects. 

And the second part was now I had to figure out, now it's stable, the second step become more difficult is how am I going to get it inside my body? Because, as you know, nothing gets inside my body. 

The real research started at that point. I tried to identify now how can I get this molecule inside the body. And that led another two years of my career, which we figured out how am I going to take this molecule and literally make this such a small size that it can go through any part of your body. 

So that's my second part. That’s when we have patented half of it. The other half, we never revealed how we did it. 

13:06 Rebecca Gadberry: And when you patent, you have to reveal how you did it. So it can’t be patented if you want to keep it private. 

13:12 Dr. Nayan Patel: Half of it. So we have patented the whole molecule and everything else, but we did not tell them the procedure on how we got there.

13:21 Rebecca Gadberry: Once you get it into the body, what's it going to do? 

13:24 Julie Falls: Wait, wait, wait. How does it get into the body? 

13:26 Rebecca Gadberry: I guess that's a good question. 

13:28 Julie Falls: Is it something you swallow or inject?

13:31 Dr. Nayan Patel: No. So what we found out was anything that goes through inside, your body has the enzymes to break any protein molecules into pieces. It breaks into amino acids and the body absorbs amino acids. So I had to figure how to get it through your skin, because the skin bypasses all those defense mechanisms we have built into your buccal membranes and your stomach and intestines.

So the delivery is through your skin. And then different concentrations, I can go skin deep or I can go all the way inside. I can literally time it where I can go as far inside your body as I want to. For the skin, it's pretty easy because it only has to go through like six or seven layers of your skin cells, and then basically all your skin cells are saturated. That’s what we did.

14:26 Julie Falls: Is it customized for individual? Almost like a compound type of thing? Because you said depending upon, you can go deeper. 

14:37 Dr. Nayan Patel: It is not customized on individual. It's customized based on human needs. If your needs are inside your body, like you have to— if you want to measure your glutathione levels in your blood, it's a different formulation, versus if you just want glutathione levels in your skin and to have skin benefits of it.

14:59 Julie Falls: So, I've been taking for quite a while. First, I was taking it liposomal and then it got so expensive. So now I'm taking NAC. So is this all waste? Am I just urinating it immediately?

15:15 Dr. Nayan Patel: No. NAC is probably the best choice you have out of all the choices of glutathione available as of today, because NAC is actually giving you the cysteine molecule to have your body's ability to produce its own glutathione endogenously, so within your cells. NAC is probably the best option you have, but then you're depending on your body's ability to produce the glutathione based on the enzymes and the amino acids additional to cysteine you need to produce glutathione. That's a good sign. 

The liposome forms of glutathione, unfortunately, there was a study done at Texas University in 2010 where they did a series of patients on this liposome forms, and they had 0% increase in the red blood cells levels of glutathione but they had appreciative increase of all the various amino acids immediately. So they saw rise on cysteines, glycines, glutamic acid, and taurine, which is another amino acid that comes out. It has nothing to do with glutathione but there was a rise of all these amino acids in the bloodstream, but no rise of glutathione. 

Eventually, of course, your body will take those three molecules, three amino acids, and produce its own glutathione, but that wasn't part of the study. The study was to see if it gets absorbed in your body or not. And the answer was no. 

16:46 Julie Falls: But merely taking the NAC, obviously, is not enough. So using your formula, what would the benefits be, in addition to the NAC or instead of the NAC?

17:01 Rebecca Gadberry: Well, Julie, when you say formula, that usually means a finished product. I think what we're talking about here is a delivery system that would probably go in a finished product or a formula. So there's a big difference. Am I wrong here, Dr. Patel? 

17:18 Dr. Nayan Patel: Yes. So, it is part of the ingredient, but, unfortunately, even the finished products, you cannot change it. There's not too many variations of this finished product as well because, literally, this is such a small and stable molecule that it cannot go into any creams you want, unfortunately. 

17:37 Rebecca Gadberry: So the environment is also part of, basically, your stability or delivery aspect of that molecule. 

17:46 Dr. Nayan Patel: Again, as I said, it is such a small molecule. It's very, very fragile and it's very delicate. That way it's not like you can take this glutathione molecule in this special form and put into dozens of different cream system that's out there that you can apply on your face and get the glutathione benefit out of it, unfortunately. 

18:09 Rebecca Gadberry: And you've put this into a spray. Is that correct? It's not a cream. It's a spray. 

18:16 Dr. Nayan Patel: The most active form is a serum. You can either spray it on or we have it in the small pump bottles that you can apply on your skin directly. And then, again, we had to figure out a way how to make the creams out of it. So we do have some facial creams that we made out of it. But, again, you're right. The main product is the serum because that will get you the most amount of benefits you're going to get from glutathione in this topical form, yes. 

18:49 Trina Renea: And that goes into your body into the cell that, or it creates glutathione in your body? 

18:57 Dr. Nayan Patel: It does not create, it gets inside your cell. The question you asked me earlier, is it a waste to take NAC or why do we need the glutathione from outside sources? The reason is because when you need glutathione, you need today now, you need three weeks from today. If you take NAC or any of the amino acids, it's going to be a while before the body takes those amino acids and produces glutathione in its appreciated levels so you can use it up. 

What we are saying is that if your needs are now, because, for example, let's say you go out and get a sunburn. Your skin is super oxidized. It's damaged and the oxidative stress on your skin is so high that you need the help now, for the next one minute. You can't wait for three weeks for your body to produce enough glutathione.

So to quench all those oxidative stress markers when you get something like burns like those, you need to apply the glutathione straight up and you can see magic happen instantaneously. The pain is gone. I'm not saying the skin is going to be healed right away, but the pain is gone because the pain is because of the oxidative stress markers that have been created when you're actually having excessive exposure to sun or, God forbid, laser treatments or whatever you do.

20:26 Dr. Vicki Rapaport: Can I ask you a question about ranking the antioxidants? As we know, vitamin C is the darling antioxidant of the skincare world and it's the most potent. And there's resveratrol and there's vitamin E. How does glutathione rank up against vitamin C? 

20:43 Dr. Nayan Patel: We consider glutathione as the mother of all antioxidants. The reason is because glutathione is, by far, the most powerful antioxidant in the world, and we produce it internally ourselves. 

Now, I'm going to say something controversial that may not have been published anywhere, but I'm just going to say it. 

21:06 Rebecca Gadberry: It's now published here, yes. 

21:09 Dr. Nayan Patel: We can have a dialogue about it. I truly believe that vitamin C is actually not an antioxidant. Now, I’ll tell you why. Vitamin C is a pro-oxidant and, at low doses, it gives enough energy to oxidize a form of glutathione to regenerate itself to make into glutathione. 

To give an example, glutathione, when it gets oxidized, becomes oxidized glutathione, GSSG molecule. Very technical. That molecule is stable inside your body and that molecule will accept energy sources from vitamin C-type chemicals and make glutathione out of it again. So, at low doses, what vitamin C is actually doing is giving up his energy to actually regenerate glutathione back to life, and that's where the antioxidant effects are coming from.

22:08 Rebecca Gadberry: It gives up the electron. 

22:11 Dr. Nayan Patel: Its electron. Exactly. And after the electron is given to all the oxidized glutathione, all the leftover vitamin C is actually a pro-oxidant. That's why if you see on the medical side, they use high-dose vitamin C infusions. High-dose vitamin C is why? Because at higher doses, it becomes a pro-oxidant. 

Now, vitamin C is a very simple molecule. I don't think so. It works in two different phases. At low doses it's an antioxidant, at high doses it's a pro-oxidant. No. Vitamin C is not that smart. It's a pro-oxidant to begin with. It's just at low doses is reviving glutathione back to life. 

22:55 Rebecca Gadberry: Okay. So here's going to be a shock for you, because back in 1997-1998, when I first started working with vitamin Cs in skincare products, the research I did said it was a pro-oxidant. So what you're saying does not come as a surprise to me at all.

And when I formulate, I put in vitamin E and vitamin C because they regenerate each other through this ion transfer that we were just talking about. It's my understanding that glutathione is the master antioxidant, helps to support the activity of other antioxidants that then not only work on reducing oxidation, but other types of free radicals that work on, like our carbon radicals and nitrogen radicals. It helps to organize your whole antioxidant defense mechanism, so to speak, which is why we call it the master antioxidant. Is that right? 

I'm clearing all of this with you. I didn't do the research. You've done the research and you wrote the book. So I just want to get some answers on what I know. 

24:05 Dr. Nayan Patel: Absolutely. That is exactly correct. That's how, because glutathione, besides the antioxidant effect, is considered the mother of all antioxidants because it also helps you detoxify the organisms that is actually causing the oxidative stress in your body as well. It's the only molecule in the body that can do both. Take electrons, charge electrons outside your body, as well as the chemicals that are actually causing the oxidative stress on a regular basis inside your body. It can clean up both of them at the same time. 

24:44 Rebecca Gadberry: And it also detoxifies chemicals like— what is it? I'm not thinking about it right now. I want to say cytochrome P450, but that's not the name of it. 

24:58 Dr. Nayan Patel: That’s the enzyme. That's the enzyme of the liver. It activates the enzyme to help clear some of the toxins, yes. 

25:04 Rebecca Gadberry: That go naturally or cleaned out naturally by the liver.

25:06 Dr. Nayan Patel: That's right. 

25:07 Julie Falls: It's funny because I take a vitamin C formula every day that is the delivery system is they call it a smart liposomal nanosphere.

25:19 Rebecca Gadberry: That's pronounced liposomal. 

25:22 Julie Falls: Liposomal. Thank you.

25:23 Rebecca Gadberry: You're welcome. You're welcome. 

25:25 Julie Falls: I know we're not supposed to say products, but it's Lypo-Spheric. I've been taking that forever. Does that mean that there's actually some glutathione in that vitamin C or it's just the delivery system?

25:38 Rebecca Gadberry: And the reason that we used vitamin C and it works on colds is because that pro-oxidation that it has, it actually helps to send pro-oxidants or free radicals at bacteria and other bugs that cause disease and cause colds. That's how it's working, not as an antioxidant. Is that correct, Dr. Patel? 

25:38 Dr. Nayan Patel: Yes, it is. That's why vitamin C has been used at higher dosages for flu and colds for years.

But we just finished our first human trials. It's about to get published. When that comes out, you may not need your Lypo-Spheric liposomal vitamin C anymore for that.

26:22 Rebecca Gadberry: Are you going to be using this technology for other molecules besides glutathione? 

26:29 Dr. Nayan Patel: We are. Our patent includes all major antioxidants. So we are able to deliver vitamin C, which is a very simple molecule, carnosine, DMAE, which is another fish protein. It's all for skin benefits. Resveratrol, cycloastragenol. 

26:50 Rebecca Gadberry: Will you be able to stable resveratrol? Because that's a real bear to stabilize. 

26:54 Dr. Nayan Patel: Yes.

26:55 Rebecca Gadberry: Really?

26:56 Dr. Nayan Patel: That's a very difficult one to make also because we had to get resveratrol that is as clean as a pharmaceutical grade product because resveratrol carries a lot of impurities inside. And so the best resveratrol in the world for cosmetic is not even close to good-for-human consumption. So we had to get the cleanest form of resveratrol to actually work with, because to get the nanoparticles too low, I cannot work with mediocre-grade material. It has to be the highest-grade materials. 

27:33 Rebecca Gadberry: And resveratrol, from what I understand, is very remarkable because it works with what we call the sirtuins in your nucleus. So it helps to slow down cell replication if there's damage to the DNA so that the cell can repair that, and then it releases the cell to go back into duplicating again. So it helps to repair any genetic damage that might be in the cell. And I'm saying any. It's not any. It's whatever it can before the cells picks up again.

I love resveratrol. I've been taking it for years in a liposome, as a liposomal material. 

28:21 Trina Renea: Is that why your skin looks so beautiful?

28:24 Rebecca Gadberry: Yeah, right. I always question when she says that, Dr. Patel, because I just…

28:30 Trina Renea: She does have beautiful skin. 

28:32 Julie Falls: Yes. What are the things at the end of the…

28:36 Dr. Vicki Rapaport: Telomeres.

28:37 Rebecca Gadberry: Telomeres, yeah. 

28:37 Julie Falls: So that the resveratrol has something to do with the telomeres. 

28:40 Rebecca Gadberry: Telomeres, I don't know if resveratrol helps to protect the telomeres. 

28:47 Julie Falls: Keep them from burning out. 

28:50 Rebecca Gadberry: Yeah, from fraying. The telomeres are at the end of the DNA strand. It's like that little—I forget the name of it, there's actually a name for that little protective thing that goes on the end of your shoelace.

29:01 Trina Renea: The shoelace enzyme.

29:03 Rebecca Gadberry: Yeah. There's just many repeating units of the same genetic material. Every time a cell replicates, a little bit gets torn off or dissolved away. And I don't know if resveratrol does this, I've worked with other materials that do it, but it actually protects it from being torn away or it can actually help lengthen it. But the problem, if we lengthen it, then that's what cancer does. So we have to be very careful in the materials that we use to make sure that that's not going to cause cancer.

Dr. Patel, do you know if resveratrol works on telomeres? 

29:50 Dr. Nayan Patel: It's my understanding that majority of the antioxidants protects the telomeres from defragmenting. 

29:59 Rebecca Gadberry: Okay. If they can get into the nucleus or they have to be made there. 

30:03 Dr. Nayan Patel: Yeah. Resveratrol is one of the most difficult molecules to get inside your body correctly. I have not come across any studies that can actually link resveratrol straight to telomeres, but I know for a fact that they have shown glutathione doing the same thing.

30:20 Rebecca Gadberry: I was just going to ask you, how does glutathione compare to resveratrol? 

30:26 Dr. Nayan Patel: The research lab that got the Nobel Prize for telomeres lengthening, if you look at the research, Dr. Bill Andrews and Blackburn’s and all those things, this would talk about is that the mother of all antioxidants have to be optimized for the telomeres to have a fighting chance to survive.

Forget lengthening. We're not even talking about lengthening. We're just talking about keeping it intact. So in their arsenals of treatment, glutathione is the number one thing that has to be there to protect it from getting damaged.

31:02 Dr. Vicki Rapaport: I have a question about food. Can I ask about the foods that contain…?

31:05 Rebecca Gadberry: Hold on just a second, because I have a question that leads right off of what he was saying. 

31:09 Dr. Vicki Rapaport: Yeah, go ahead. 

31:10 Rebecca Gadberry: That is when we talk about stress, I know that stress, like big, concentrated chunks of stress or long-term stress, like caring for a parent for several years, shortens the telomeres very quickly and that causes you to age faster and shortens your lifespan. Glutathione, when we talk about it being de-stressing, is that part of what we're saying? Is that it works with that stress reaction?

31:39 Dr. Nayan Patel: When you have a stress reaction, it has produced a lot of oxidative components. Those oxidative components have to be quenched really fast, and that's where the glutathione comes into play. Even though glutathione may not be de-stressor, but what it does is that all the damage that the stress molecule can cause a body has been neutralized immediately if you have enough glutathione.

I cannot get rid of the stressors, but what I can do is I can get rid of the electronic components that cause the stress reactions in you body with glutathione.

32:17 Rebecca Gadberry: Got it. 

32:19 Dr. Nayan Patel: Some of the stressors of course you can remove them, like organic phosphates and organic chemicals that you consume from your diet and exposure through your skin. Those can be detoxified in small amounts by glutathione. 

But, more importantly, we have millions and millions of reactions happening every single second in your body. That reaction byproduct is an electronic waste that needs to be quenched, that needs to be detoxified. That's why you never stop aging because we never stop chemical reactions. If we can quench all the electronic waste out of your system, you can literally put a break on your aging process right then and there. I'm not saying you can reverse aging, but you can put a break on it immediately. 

33:06 Julie Falls: Have you seen actual results in yourself or your patients that you could share with us and tell us about?

33:13 Dr. Nayan Patel: Oh, my gosh. I did not release any of my products until 14 years after doing my research. So, 14 years I've been giving it to my patients, my family. They have been my, sort of... 

33:31 Trina Renea: Test patients. 

33:32 Rebecca Gadberry: Guinea pigs, yes.

33:37 Dr. Nayan Patel: I'm an animal lover. I don't call them pigs. 

33:39 Rebecca Gadberry: We use humans instead of animals for testing. 

33:44 Dr. Nayan Patel: I'm fortunate to be working with so many physicians so, yes, we have a lot of studies being done. The book that I wrote The Glutathione Revolution is all about the stories that I've collected over the years from my patients, but that is on the medical side. All of them are in the medical side. 

On the skincare side, I never did any study until about a year ago, not even a year ago. About eight months ago when I did my first study on human patients for skincare. The company that did the study for us, when the results came out, they were looking at about 20 categories. And the company says they have never seen anybody in all 20 categories have over 80% success rate ever.

34:26 Rebecca Gadberry: What kind of categories? 

34:28 Dr. Nayan Patel: They're talking about skin pigmentations and wrinkles and spots and firmness. 

34:37 Rebecca Gadberry: You name it for aging it works. 

34:40 Dr. Nayan Patel: It's aging, yeah. And the people always ask us, they said, “What does glutathione do for aging skin?” I said, “I don't know.” Because we do not actually know what excess electrons in your body how much has it damaged your skin. Some people get age spots. Some people get wrinkles. Some people get the thinning of your skin, of less collagen production. Some people have reduced blood flow.

I mean, there's so much different variations of what you can have and the glutathione may not be affecting all of them, but it's absolutely going to quench all those free radicals so the damage is going to stop right then and there. It gives the body the chance, a fighting chance to heal itself. 

I always say that. Our body is self-sufficient. It can fight his own problems. It can self-heal itself. It just needs to make sure that it has a fighting chance. And glutathione is a savior for them. It gives a chance to heal. 

35:37 Trina Renea: Like, if you're stressed out and you spray some glutathione on your belly, you'll be less stressed and less damage to your— you won't get cystic acne and stuff? That's really basic. I'm dumbing it down for people. What is this glutathione going to do for them? 

35:59 Dr. Nayan Patel: No, no, no, no. It doesn't. I mean, I wish it can do that part. Then, oh, my God, then everybody in the world would be using the product today. But that's not the purpose. 

First of all, the cause of stressors is more important. It's not going to remove the cause of stressors. If we have a financial problem, spraying glutathione on your body is not going to remove the financial problem away. It's going to probably remove the damage that's caused by the stressors. So that's understandable. 

But unless you remove the financial problem that's causing this electronic stress in your body, you're going to be somewhat taking this product for the rest of your life. That's not the purpose that glutathione needs to be. The purpose of glutathione is to help your body heal itself from internally, because external stressors are always going to keep on coming and keep on changing. But you have 80% of your stress in your body or even more is internal. Chemical reactions, infections…

37:00 Rebecca Gadberry: Immune system.

37:01 Dr. Nayan Patel: Disease that you get.

37:02 Rebecca Gadberry: Lowered immune system. 

37:05 Dr. Nayan Patel: Yeah. And so those stressors are probably the most toxic to your body than having a financial problem or mental stress problems or somebody just cut you in front of your car this morning when you drove to work. Those stressors I call a fight-or-flight type of stressors. 

37:24 Rebecca Gadberry: So if you've got those stressors, and those are temporary stressors, I mean, they may go on for a long time, but how you choose to respond to them is also how much stress they put on your body. But if you have those stressors, then using this spray would help you get through the crisis point, perhaps, that the stress would create by giving you that extra boost of glutathione that you need more than what your body is already making. 

37:53 Dr. Nayan Patel: That's exactly right. What you're getting is glutathione on demand, because your need just arose right now. If you take any other form of glutathione, it's not going to improve it. Even if you take intravenous form of glutathione, it's in and out of your body in 14, 15 minutes and the stressors, the stress is not going to go away in 14, 15 minutes, right?

38:13 Dr. Vicki Rapaport: And then what about if you eat the foods rich in glutathione? Because I know a lot of people want to approach this from a dietary aspect. Does that help or not help? 

38:23 Dr. Nayan Patel: Yes, it does. In my book, I have a 14-day plan to boost a glutathione. It's just a fancy marketing term, 14-day diet, but that’s actually my diet for the last 27 years. That is what I eat for every single day. 

38:39 Rebecca Gadberry: You just repeat it every 14 days.

38:40 Trina Renea: Can you just give us a little clue as to what that kind of is? Like a mini version? 

38:45 Dr. Vicki Rapaport: It sounds like a lot of green vegetables, I think.

38:47 Dr. Nayan Patel: A lot of greens. A lot of greens, 30 to 40 different types of variety of foods every single day. Even if you put like a bunch of spices, there are six or seven different types of spices inside is also considered one different food, right? So anytime you have a whole slew of variety, is what you need. 

It doesn't have to be just vegetables, even though I chose to become vegetarian. Well, I would say pescatarian right now. I like my fish once in a while, probably once a month, once every other month, but I still have that. But mostly, it's the vegetable diet. It's all kinds of greens, all kinds of colors. 

And what it does, it will increase your glutathione levels because it reduces the stressors in your body. Your need reducers so if you have more supplies than the actual needs, guess what happens? Now you say, “Oh, my God, I'm producing a lot more glutathione.” In actuality, your needs have reduced. And that's what I like. 

39:59 Dr. Vicki Rapaport: Would you just give us, because I love specifics, would you give us an idea of a breakfast, a lunch and a dinner that you have been eating for the last whatever you said, 27 years or 14 years? What did you say?

40:13 Dr. Nayan Patel: Yes. I know. So, breakfast is my worst meal of the day because I always get up and I'm on the go. So breakfast, I used to always have had a shake, which is like a superfoods green. Not the best way to take your greens, by the way, by all means, but that's the easiest way I can get a serving of about 30 different varieties of greens in my day. 

But when I take those greens, I always take some enzymes because you can digest those greens better if you have enzymes with it. I have a protein. The protein is usually a whey protein type molecule. The reason I like whey is because it has cysteine in there, which helps produce glutathione for us. So I like the whey proteins. 

And I usually put very little berries inside. I just have bananas once in a while, but I like to mix up all my fruits. So I put a little bit of berries, little banana sometimes, a little bit of fruits, whatever I have, but nothing more than like a small handful of it. Not too much. 

I would love to have all greens in my shakes in the morning for the breakfast, but sometimes I don't have time for that either so I just put a scooper inside.

For the last two years, I've cut out completely my breakfast out. I don't have any more breakfast anymore because I am more interested in autophagy, on cell death. And so now, I have reduced my diet to reduce dramatically, so I don't have breakfast anymore. 

41:43 Trina Renea: Intermittent fasting. 

41:45 Dr. Nayan Patel: Yeah. I used to have that before, but not anymore. What I’ve done is I have moved my breakfast, a shake that I used to drink, to now after 1:00, the same exact shake. It hasn’t changed, just moved to 1:00 now and yet I usually have my salad bowl. Every day, I have fresh salad. Every single day. Thank God we're in California. We have fresh fruits and vegetables available to us and we are so blessed to be staying in the state that we can enjoy the fresh vegetables every single day. 

So I have it every single day for the last 27 years. I'll have my bowl of salad with very minimal dressing. I like my dates as my cheat. I like to have my one date or two dates sometimes, it depends on…

42:30 Dr. Vicki Rapaport: That’s amazing.

42:31 Rebecca Gadberry: Chopped up really tiny so they're flavor bombs. 

42:33 Julie Falls: Any nuts? Nuts in there?

42:35 Dr. Nayan Patel: Yes, of course. I have my raw nuts, usually walnuts is what I do. I try to stay away from peanuts and cashews and things like that, even though I love those nuts, pistachios and things like that. But then those are usually on my cheat days, if I'm having a drink or something with my friends, I'll probably have those nuts, because that’s a cheat day so all rules are off. But yes, I do have some walnuts on an everyday basis. 

Sometimes almonds. Almonds have to be soaked the night before, so that’s always hard because I forget. But walnuts, I have them every day.

Then the dinner is also small. Same vegetables but this time it's cooked vegetables and lentils. So that's going to get me my protein that I need. It's not the best, but it's enough. 

43:32 Rebecca Gadberry: The question I think that Vicki asked was which foods are rich in glutathione. But I was under the impression they're rich in the amino acid to make glutathione, not the glutathione. 

43:45 Dr. Nayan Patel: That's exactly right. 

43:47 Rebecca Gadberry: Okay. So what foods are rich in those three amino acids? And what are they again? Cysteine…

43:54 Dr. Nayan Patel: Glutamic acid, cysteine and glycine.

43:57 Rebecca Gadberry: Glycine. And glycine is also really good for collagen as well.

44:03 Dr. Nayan Patel: Yeah. So, your body produces enough of glycine, glutamic acid. There's enough in the diet that you get. What you do not get is cysteine, a lot of it. And cysteine is usually animal source. So since I don't want to eat animals, I do get my cysteine from whey isolate proteins from the milk products.

44:20 Rebecca Gadberry: That’s it. Okay. 

44:23 Trina Renea: From the whey protein, protein powder with whey?

44:25 Rebecca Gadberry: Yeah. 

44:26 Dr. Nayan Patel: The protein powder with whey, but you can also eat broccoli, asparagus. Of course, if you like oysters that has a lot of components to build your glutathione in there as well. Cruciferous vegetables will have those. 

But, nowadays, you can just put it in your favorite search engine, ‘high in cysteine, high in glutamic acid…”

44:50 Dr. Vicki Rapaport: That's a good tip, actually. 

44:51 Dr. Nayan Patel: And the whole list comes out. This search engine has made me extremely lazy now, in fact.

44:59 Rebecca Gadberry: Yes. Absolutely. 

Now, you were talking about autophagy or autophagy. I think Dr. David Sinclair, who's done a lot of work on longevity, and I've always pronounced it autophagy, he pronounces it autophagy. How do you pronounce it? 

45:18 Dr. Nayan Patel: Autophagy. 

45:19 Rebecca Gadberry: Autophagy. I'd love to hear more about that. I'm actually thinking now that this is a whole other topic, talking about autophagy and the skin and the body. I'm actually working on three products right now in my lab to work on autophagy for the skin, and there aren't a lot of ingredients. I've actually had to go into South America to look for them because they're not unique to the United States.

But I've also been doing intermittent fasting for two-and-a-half years and swear by it. It sounds like you do too. And intermittent fasting kicks us into the autophagy. What is autophagy, just very simply? And would love to do another podcast on this because it does have such a strong effect on the skin.

46:15 Dr. Nayan Patel: Absolutely. I would love to come back again whenever you want me to again. We can dive deep into that part, because that's an interesting topic. It may not be affecting skin health immediately, but it's absolutely great for longevity. Mainly, it's for your brain health, because neuroplasticity, neurology is more about anti-aging than anything else. You can look good but if you’re brain dead, you're useless, right? 

So I definitely want to talk about those whenever you want me back.

46:53 Rebecca Gadberry: Now, does autophagy also trigger glutathione production?

46:58 Dr. Nayan Patel: Not that I know of. Because glutathione production is based on your actual needs for detoxifying. Glutathione may help remove some of those dead cells or what we call zombie cells out of your body, but it is not triggering autophagy. It can help you reduce your insulin loads down, so maybe that's some part of it, but sometimes we need the insulin, actually, for the dead cells to kind of revive so it can go through the process and kill themselves or get out of your body.

Some of these cells are kind of dormant at all times, and you don't like dormant cells revolving in your body the whole time. It's a whole other topic. 

47:44 Trina Renea: Let's definitely have him back for a deep dive on autophagy.

47:47 Rebecca Gadberry: Yeah, because zombie cells are really interesting too.

47:51 Julie Falls: Yeah, ____ to have that.

47:52 Rebecca Gadberry: Yeah, these zombie cells they're your senescence cells or cells that go into a non-productive state. Now, I'm learning that you have these zombie cells and they release chemicals that create other zombie cells. In the skin, those zombie cells actually spread the chemicals throughout your body. 

48:12 Trina Renea: That would be a really scary movie. 

48:13 Rebecca Gadberry: Yeah, the zombie cells. 

48:16 Trina Renea: The Zombie Cells.

48:18 Rebecca Gadberry: What I asked was, and I want to make sure that we understood each other, does autophagy trigger GSH? Not does GSH trigger autophagy, but does autophagy trigger GSH production?

48:34 Dr. Nayan Patel: I'm not sure about that one. I don't think so, but, again, that is just my initial reaction because there is no direct correlation. There may be some secondary effect that may be causing the stimulation of glutathione production, but there's no for sure, though. I'm not sure if there's a primary reason why we have produced more glutathione. 

48:55 Rebecca Gadberry: And if you're interested at home in autophagy, tune in for that episode and we'll explain what it is. 

49:01 Trina Renea: Yes, coming up later this year. 

49:03 Rebecca Gadberry: Yes. 

49:05 Trina Renea: All right. Well, I think we can wrap this up. And, definitely, we will put all your information up on our end so that people can see where to find more information about you and about your book and ingredients and products and things. 

So, we really, really appreciate you coming on and talking to us about glutathione. I love that there's a way to get it into our bodies now and it's so helpful in longevity.

49:34 Julie Falls: So much information. So much we've learned. 

49:35 Trina Renea: Amazing. 

49:35 Julie Falls: Thank you so much. 

49:36 Rebecca Gadberry: And it sounds like the work that you're doing is not just for the skin, but spraying some of the versions, of which we're working on, on the body will help the body inside, not just the surface of the skin.

49:54 Dr. Nayan Patel: You're absolutely right. As a pharmacist, and I work with physicians, all my research has been for internal use for clinical outcomes. The skin benefit I saw early on, because my family was using the product and their skin was glowing. All my sister-in-laws and my wife's friends are asking me said, “Oh, my God, can you make some skincare for me with this product inside?” So that's how the whole process started.

And so I was not going to make such a typical skincare routine, so what I actually did, which is very unique, is with the technology, I took all the known chemicals that I think were great, which includes glutathione, of course, vitamin C, carnosine, has an antioxidant effect that keeps on increasing, co-enzyme Q10, resveratrol, cycloastragenol, and I took all those products and gave everything at full concentration in two creams. 

50:54 Rebecca Gadberry: Wow. That’s awesome.

50:56 Dr. Nayan Patel: So that’s what we did. 

50:57 Rebecca Gadberry: And they don't oxidize. That's the trigger. 

50:59 Dr. Nayan Patel: They don't oxidize. It delivers your skin and the results are literally in 30 days or less. 

51:07 Rebecca Gadberry: Wow. Well, we're going to have a link in the notes page. 

51:09 Julie Falls: I think we need samples.

51:11 Rebecca Gadberry: We do. We need truckloads, not samples. Truckloads. We're going to have a link at the bottom of our Notes page for the podcast, where people can just click and find out more about what you're talking about here and also find out more about you.

We just really, really have enjoyed this conversation and learned so much and what we can do for ourselves. 

51:36 Trina Renea: Thank you for joining us.

51:39 Dr. Vicki Rapaport: I feel already more healthy. 

51:41 Rebecca Gadberry: Yeah, just by talking to him. 

51:42 Dr. Vicki Rapaport: Just having the information. 

51:44 Julie Falls: Just hearing about his diet, you know. 

51:47 Dr. Vicki Rapaport: Yeah, it's incredible.

51:47 Rebecca Gadberry: And I planted my vegetable garden yesterday, so I'm right on track for this conversation. 

51:51 Trina Renea: I have his book, so I'm going to go home and look at the 14-day plan and try and make it a lifestyle. 

51:57 Julie Falls: Good luck. 

51:58 Dr. Vicki Rapaport: You're going to read the book, you're going to plant your garden, you're going to get samples. 

52:01 Julie Falls: And I have Erewhon around my corn.

52:03 Dr. Vicki Rapaport: I love Erewhon. 

52:05 Trina Renea: That's really expensive. 

52:07 Julie Falls: I knew you were going to say that. 

52:07 Dr. Vicki Rapaport: Thank you. 

52:09 Rebecca Gadberry: It was a joy speaking with you. 

52:10 Julie Falls: Thank you so much. So nice meeting you. 

52:14 Dr. Nayan Patel: Likewise. Thank you.

52:14 Dr. Vicki Rapaport: Thank you, Dr. Patel. 

52:15 Rebecca Gadberry: Thank you, Dr. Patel. 

52:16 Trina Renea: We'll talk to you soon. 

52:17 Dr. Nayan Patel: All right. Thanks. 

52:18 Trina Renea: Bye. 

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